Yuan Gao . Dong-Sheng Zhou . Ping Hai . Yan Li . Fei Wang

Received: 2 September 2015 / Accepted: 24 September 2015 / Published online: 29 September 2015

© The Author(s) 2015. This article is published with open access at Springerlink.com

Abstract

Five new hybrid monoterpenoid indole alkaloids bearing an unusual 2,2-dimethyl-4-oxopiperidin-6-yl moiety, namely rauvotetraphyllines F–H (1, 3, 4), 17-epi-rauvotetraphylline F (2) and 21-epi-rauvotetraphylline H (5), were isolated from the aerial parts of Rauvolfia tetraphylla. Their structures were established by extensive spectroscopic analysis. The new alkaloids were evaluated for their cytotoxicity in vitro against five human cancer cell lines.

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