Li-Xia Wang . Hai-Rong Zheng . Fu-Cai Ren .Tian-Ge Chen . Xiang-Mei Li . Xian-Jun Jiang . Fei Wang

Received: 15 December 2016 / Accepted: 10 January 2017 / Published online: 21 January 2017

© The Author(s) 2017. This article is published with open access at Springerlink.com

Abstract

Four hitherto unknown polysubstituted isoflavonoids, including three isoflavans: 7,4’-dihydroxy-8,2’,3’-trimethoxyisoflavan (1), 7,2’,4’-trihydroxy-8,3’-dimethoxyisoflavan (2), and 7,2’,4’-trihydroxy-5-methoxyisoflavan (3), and one prenylated isoflavone cudraisoflavone M (4) were isolated from the ethanol extracts of Spatholobus suberectus (for 1 and 2), Flemingia macrophylla (for 3), and Cudrania cochinchinensis (for 4), respectively. Their structures were established on the basis of extensive spectroscopic analysis. Compounds 1 and 4 exhibited weak cytotoxic activity against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480).

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